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PRA 10025
Product Information Molecular Structure


Notes: This nucleoside shows immunosuppressive and antiinflammatory activity.

Description: This nucleoside shows immunosuppressive and antiinflammatory activity, e.g. by inhibiting cellular interactions that result in the lysis of antigen-bearing target cells, a “killer cell” phenomenon thought to play a role in tumor and graft rejection (Krenitsky, T. A.; Rideout, J. L.; Chao, E.; Koszalka, G. W.; Gurney, F.; Crouch, R. C.; Cohn, N. K.; Wolberg, G.; Vinegar, R., J. Med. Chem. 1986, 29, 138-143). When 3-deaza-dA is incorporated into oligonucleotides, the adenine N3 nitrogen is absent in the minor groove, thus providing a useful probe for studies of electrostatic interactions in this region of DNA (Maki, A. S.; Kim, T.; Kool, E. T., Biochemistry, 2004, 43, 1102-1110) as well as how different DNA polymerases use the N3 nitrogen as a substrate specificity determinant (Hendrickson, C. L.; Devine, K. G.; Benner, S. A., Nucleic Acids Res., 2004, 32, 2241-2250).

Product Details Product Pricing

MF: C11H14N4O3

MW: 250.26

CAS NO: 78582-17-9

Storage Conditions: 5 oC



Stock maintained. Ships within 1-3 days.

Unit Weight Unit Price Quantity
25 mg $250.00
100 mg $705.00
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