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HC 9070
Product Information Molecular Structure

7-O-Amino-4-methylumbelliferone

Notes: Useful in a simple spectroscopic assay for aldehydes in biologically relevant media.

Description: Coumarin derivatives such as 7-O-Amino-4-methylumbelliferone have been shown to be useful in a simple spectroscopic assay for aldehydes in biologically relevant media.1 Condensation of this compound with aldehydes (e.g., formaldehyde) forms aldimines that are susceptible to elimination with Lewis bases such as bovine serum albumin (BSA), forming blue-fluorescent 4-methylumbelliferone (4-MU). The excitation and emission maxima for 4-MU are the same at pH 7.0 (water) and pH 10.3 (0.15 M glycine buffer).2 Maximum fluorescence was observed at 445 nm when excited at 365 nm, and the fluorescence intensity is 100 times as intense at pH 10.3 than at pH 7.0.

5 mg = 26.2 micromoles; 25 mg = 131 micromoles.

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1. Salahuddin, S.; Renaudet, O.; Reymond, J.-L. Org. Biomol. Chem. 2004, 2, 1471-1475.

2. Strachan, R.; Wood, J.; Hirschmann, R. J. Org. Chem. 1962, 27, 1074-1075.

7-<em>O</em>-Amino-4-methylumbelliferone
Product Details Product Pricing

MF: C10H9NO3

MW: 191.18

CAS NO: 99908-11-9

Storage Conditions: -20 oC, dark

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

7-(Aminooxy)-4-methyl-2H-chromen-2-one
Unit Weight Unit Price Quantity
5 mg $100.00
25 mg $305.00
 
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