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FC 8190
Product Information Molecular Structure

DTPA-Quinolone-TEG azide

Notes: This product has been discontinued

Description: A number of luminescent probes wherein lanthanide ions are chelated to organic chromophores have been reported by Mustaev, et al.1-6 FC 8190 is our first product for this approach to luminescence.7 We now provide the organic molecule that lets you add the lanthanide of your choosing to complete the luminescent probe that best suits your needs. The design of FC 8190 incorporates three elements in a single organic molecule that sequesters lanthanide ions: (1) a diethylenetriaminepentaacetic acid (DPTA) fragment, which serves to chelate Lanthanides such as Eu+3 or Tb+3; (2) a quinolone chromophore, which serves as an antenna for ultraviolet light; and (3) a hydrophilic tether with a distal azide, which provides a site for conjugation to biomolecules via the click reaction. The luminescence exhibited by such organic lanthanide chelates makes them useful probes for investigating biological processes. The quinolone chromophore absorbs UV light and then transmits energy to the chelated lanthanide ion, which in turn emits discrete bands of visible light. The large Stokes shift, long luminescence lifetime and narrow emission bands that are observed provide the capability for highly sensitive detection.

References

1. Krasnoperov, L.N.; Marras, S.A.E.; Kozlov, M.; Wirpsza, L.; Mustaev, A. Bioconjugate Chem., 2010, 21, 319-327.

2. Mustaev, A.; Kozlov, M.; Marras, S.; Krasnoperov, L.; Wirpsza, L.; Pillai, S. PCT Int. Appl., 2011, WO 2011088193 A2.

3. Pillai, S.; Kozlov, M.; Marras, S.A.E.; Krasnoperov, L.N.; Mustaev, A. Prog. Nanotechnology and Nanomaterials, 2012, 1(1), 18-24.

4. Wirpsza, L.; Pillai, S.; Batish, M.; Marras, S.A.E.; Krasnoperov, L.; Mustaev, A. J. Photochemistry and Photobiology, B: Biology, 2012, 116, 22-29.

5. Pillai, S.; Kozlov, M.; Marras, S.A.E.; Krasnoperov, L.N.; Mustaev, A. J. Fluorescence, 2012, 22(4), 1021-1032.

6. a) Ge, P.; Selvin, P.R. Bioconjugate Chem. 2004, 15, 1088-1094; b) Li, M.; Selvin, P.R. Bioconjugate Chem. 1997, 8, 127-132.

7. Manufactured and sold under a license agreement with the University of Medicine and Dentistry of New Jersey.

DTPA-Quinolone-TEG azide
Product Details Product Pricing

MF: C33H47N9O14 : C3H6O6

MW: 793.78

CAS NO: None Assigned

Storage Conditions: 20 oC

Purity≥95%

Availability: 

This compound has been discontinued

Unit Weight Unit Price Quantity
0 mg $0.00
 
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