3'-BBQ-650^® CPG

Description: Our BlackBerry^® quenchers are excellent quenchers of long-wavelength fluorophores in both FRET and contact modes. They exhibit an absorption maximum at ca. 650 nm and have useful absorbance between 550 and 750 nm. The tricyclic 8-alkoxyjulolidine moiety is a powerful pi-donor that affords a surprising bathochromic shift when compared to related compounds. A key advantage of the BBQ-650^® is its stability to ammonia and oxidation conditions. Due to the lipophilicity of the quencher, cleavage from the support may be slow. Our 3'-BBQ-650^® CPG II, BL 2020 contains a diglycolate linker to facilitate cleavage. We also offer versions for incorporation into oligonucleotides internally (BBQ-650^®-dT CEP, BL 1010), or at the 5'-terminus (5'-BBQ-650^® CEP, BL 1020 and 5'-BBQ-650^®(DMT) CEP, BL 1030). In addition, BBQ-650^® NHS Ester (BL 3010) and BBQ-650^® TEG azide (BL 3030) are available for postsynthetic labeling of amine-modified oligonucleotides.