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BA 0316
Product Information Molecular Structure

Alkynyl-modifier-C6-dT CEP

Notes:  This phosphoramidite features a well-established linker that places the alkyne at a sufficient distance from the oligonucleotide to allow efficient click conjugation.


An attractive strategy for nucleic acid conjugation involves the Cu(I)-catalyzed click reaction between terminal alkynes and azides. While 5-Ethynyl-dU in oligonucleotides has been reported to undergo the click reaction,1 the short rigid nature of the alkyne group severely limits its application for this purpose. 5-Octadiynyl-dU CEP (BA 0308)1-4 is a much superior reagent for the installation of an alkyne-bearing nucleoside into an oligonucleotide when click reactions are contemplated. The terminal alkyne is more flexible and extends farther away from thr pyrimidine ring, thereby allowing more efficient ligation via click chemistry, even when multiple ligations to a single oligo are desired. Alkynyl-modifier-C6-dT CEP (BA 0316) is an analogous reagent with a slightly longer alkyne appendage that we have introduced as an alternative for oligo click ligations.

For more information on this product and its use, download a Product Information Sheet for Alkynyl-Modifier-C6-dT CEP.

For a complete listing of our reagents for click chemistry, please see our Click-matesTM Collection page.

(1) Gierlich, J.; Burley, G. A.; Gramlich, P. M. E.; Hammond, D. M.; Carell, T. Org. Lett. 2006, 8, 3639-3642.

(2) Seela, F.; Sirivolu, V. R. Chem. Biodiversity 2006, 3, 509-514.

(3) Seela, F.; Sirivolu, V. R. Helv. Chim. Acta 2007, 90, 535-552.

(4) Hammond, D. M.; Manetto, A.; Gierlich, J.; Azov, V. A.; Gramlich, P. M. E.; Burley, G. A.; Maul, M.; Carell, T. Angew. Chem. Int. Ed. 2007, 46, 4184-4187.

(5) Rozkiewicz, D. I.; Gierlich, J.; Burley, G. A.; Gutsmiedl, K.; Carell, T.; Ravoo, B. J.; Reinhoudt, D. N. ChemBioChem 2007, 8, 1997-2002.

This compound is sold under license from baseclick GmbH, and the purchase of these products for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry (“Click Chemistry”) includes a limited, nontransferable license to intellectual property owned by TSRI to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or

Alkynyl-modifier-C6-dT CEP
Product Details Product Pricing

MF: C48H58N5O9P

MW: 879.98

CAS NO: None Assigned

Storage Conditions: dry, -20 oC



Stock maintained. Ships within 1-3 days.

Alternate Name: 

Unit Weight Unit Price Quantity
100 µmol $378.00
0.25 g $835.00
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