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BA 0373
Product Information Molecular Structure

5'-Click-easy® BCN CEP II

Notes: BA 0373 is a phosphoramidite for the installation of a strained cyclooctyne (BCN) into an oligonucleotide for subsequent copper-free click elaboration.

Description: 

The click cycloaddition reaction is a remarkably efficient and reliable process for bioconjugation even in the presence of the diverse array of functional groups found in DNA and the variety of scientifically intriguing ligation partners. Our 5’-Click-easyTM BCN CEP (BA 0373)1 can be used to prepare oligonucleotides for subsequent clean and efficient copper-free click cycloaddition. In our hands, the bicyclo[6.1.0]nonyne (BCN)2 is a superior scaffold for the strain-promoted alkyne-azide cycloaddition.3

For more information, download a Product Information Sheet for BA 0373 here.

Please see our Click-matesTM Collection for a selection of click-able azides for use with this remarkable click alkyne.

References

1) Patent pending.

2) Dommerholt, J.; Schmidt, S.; Temming, R.; Hendricks, L.J.A.; Rutjes, F.P.J.T.; van Hest, J.C.M.; Lefeber, D.J.; Friedl, P.; van Delft. F.L. . Angew. Chem. Int. Ed. 2010, 49, 9422-9425.

3) Debets, M.F.; van Berkel, S.S.; Dommerholt, J.; Dirks, A.J.; Rutjes, F.P.J.T.; van Delft, F.L. Accounts of Chem. Res. 2011, 44, 805-815.

5'-Click-easy<sup>®</sup> BCN CEP II
Product Details Product Pricing

MF: C24H40N3O5P

MW: 481.57

CAS NO: 1352811-59-6

Storage Conditions: Dry, -20 °C

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

(1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethyl(2-(2-(((2-
cyanoethoxy)(diisopropylamino)phosphino)oxy)ethoxy)
ethyl)carbamate
Unit Weight Unit Price Quantity
100 µmol $320.00
250 µmol $760.00
 
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