View Shopping Cart   Checkout   Order Catalog  

BA 0357
Product Information Molecular Structure

Tocopherol-TEG CEP

Notes: Lipophilic carrier tag for internal or 5'-terminus installation in oligonucleotides.

Description: 

In the search for effective in vivo carriers for therapeutic applications of siRNAs, Nishina, Unno and coworkers utilized alpha-tocopherol (vitamin E) as a carrier molecule.1 They hypothesized that a molecule that had its own transport pathway, was essential for target tissue cells, yet was not synthesized within the cells would be an ideal in vivo carrier conjugate. Their results indicate that alpha -tocopherol is a safe and effective carrier for delivery of siRNA into the liver. Following their lead, we have modified alpha -tocopherol with the mixed polarity TEG linker, and produced the corresponding phosphoramidite (BA 0357) which is useful for modification of oligonucleotides either internally or at the 5-terminus.

Download a Product Information sheet for BA 0357 here.

For post-synthetic tocopherol labeling please see our Tocopherol -TEG azide FC 8160.

References

1. Nishina, K.; Unno, T.; Uno, Y.; Kuboodera, T.; Kanouchi, T.; Mizusawa, H.; Yokota, T. Molecular Therapy 2008, 16, 724740.

Tocopherol-TEG CEP
Product Details Product Pricing

MF: C68H103N2O10P

MW: 1139.56

CAS NO: None Assigend

Storage Conditions: Dry, -20 C

Purity≥97%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

a-Tocopherol -TEG CEP
Unit Weight Unit Price Quantity
5 g minimum order, call for pricing $0.00
 
View Shopping CartCheckout