View Shopping Cart   Checkout   Order Catalog  

BA 0350
Product Information Molecular Structure

5'-Aminooxy-modifier-11 CEP

Notes: For the synthesis of oligonucleotides bearing a 5’-aminooxy group.

Description:  The use of oxime formation in ligation reactions of oligonucleotides has been widely established in the literature for over a decade.1 As examples, 5’-aminooxy-modifiers have been used in oxime ligation for peptide-oligonucleotide conjugates,2 attachment of nucleosides to solid supports,3 and head to tail cyclization of oligonucleotides.4 The concurrent use of BA 0350 at the 5’-terminus and an indole aldehyde modification elsewhere in an oligonucleotide should permit on-support head to tail cyclization upon cleavage of the N-DMT protecting group. See Formylindole-dTCEP (BA 0301) for an example of an appropriate indole aldehyde.

For more information, download a Product Information Sheet for BA 0350 here.

References

1) For recent reviews see: a) Zatsepin, T.S.; Stetsenko, D.A.; Gait, M.J.; Oretskaya, T.S. Bioconjugate Chem., 2005, 16(3), 471-89. b) Singh, Y.; Edupuganti, O.P.; Villen, M.; Defrancq, E.; Dumy, P. Comptes RendusChim., 2005, 8(5), 789-96.

2) a) Cebon, B.; Lambert, J.N.; Leung, D.; Mackie, K.; McCluskey, K.L.; Nguyen, H.; Tassone, C. Aust J. Chem., 2000, 53, 3333-40. b) Prater, C.E.; Miller, P.S. Bioconjugate Chem., 2003, 14(2), 320-30. c) Prater, C.E.; Miller, P.S. Bioconjugate Chem., 2004, 15(2), 498-507.

3) a) Salo, H.; Virta, P.; Hakala, H.; Prakash, T.P.; Kawasaki, A.M.; Manoharan, M.; Lönnberg, H. Bioconjugate Chem., 1999, 10(5), 815-23. b) Defrancq, E.; Hoang, a.; Vinet, F.; Dumy, P.; Bioorg. Med. Chem. Lett., 2003, 13, 2683-6. c) Bincheva, M.; Scheibler, L.; Lincoln, P.; Vogel, H.; Akerman, B. Langmuir, 1999, 15, 4317-20.

4) Edupuganti, O.P.; Defrancq, E.; Dumy, P. J. Org. Chem, 2003, 68, 8708-10.

5'-Aminooxy-modifier-11 CEP
Product Details Product Pricing

MF: C38H54N3O8P

MW: 711.82

CAS NO: None Assigned

Storage Conditions: Dry, -20 °C

Purity≥90%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

5'-Aminooxy TEG CEP
Unit Weight Unit Price Quantity
100 µmol $235.00
0.25 g $785.00
1 g $2,500.00
 
View Shopping CartCheckout