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BA 0344
Product Information Molecular Structure

d5SICS CEP

Notes: Half of a novel base pair that achieves pair recognition through hydrophobic interactions.

Description: The dNaM (BA 0343) and d5SICS (BA 0344)matched pair appears to be a very interesting novel base pair, achieving pair recognition through hydrophobic interactions that rivals the A-T and G-C pairing in the natural genetic alphabet.1-7 In addition, they have been shown to be well-replicated by DNA polymerases under steady-state conditions, regardless of sequence. The fidelity and efficiency of dNaM and d5SICS replication approach those of natural synthesis. Both dNaM and d5SICS are also efficiently transcribed by T7 RNA polymerase in either direction. In 2009, the Romesberg and Marx groups reported data that showed KlenTaq polymerase induces the dNaM-d5SICS unnatural base pair to adopt a natural Watson-Crick like strucutre.8 For more information, download a Product Information Sheet for BA 0344 here.

1. Seo, Y.J.; Matsuda, S.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131, 5046-7.

2. Seo, Y.J.; Hwang, G.T.; Ordoukhanian, P.; Romesberg, F.E. J. Am. Chem. Soc., 2009, 131, 3246-52.

3. Seo, Y.J.; Romesberg, F.E. ChemBioChem, 2009, 10, 2394-2400.

4. Hwang, G.T.; Hari, Y.; Romesberg, F.E. Nucleic Acids Res., 2009, 37, 4757-63.

5. Hari, Y.; Hwang, G.T.; Leconte, A.M.; Joubert, N.; Hocek, M.; Romesberg, F.E. ChemBioChem, 2008, 9, 2796-9.

6. Hwang, G.T.; Romesberg, F.E. J. Am. Chem. Soc., 2008, 130, 14872-82.

7. Leconte, A.M.; Hwang, G.T.; Matsuda, S.; Capek, P.; Hari, Y.; Romesberg, F.E J. Am. Chem. Soc., 2008, 130, 2336-43.

8. Betz, K.; Malyshev, D.A.; Lavergne, T.; Welte, W.; Diederichs, K.; Dwyer, T.J.; Ordoukhanian, P.; Romesberg, F.E.; Marx, A. Nat. Chem. Biol. 2012, 8, 612-614.

d5SICS CEP
Product Details Product Pricing

MF: C45H52N3O6PS

MW: 793.95

CAS NO: 1010689-04-9

Storage Conditions: Dry, -20 C

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

3-(3-O-[(Diisopropylamino)(2-cyanoethoxy)phosphino]-
5'-O-(4,4'-dimethoxytrityl)-2'-deoxyribofuranosyl)-6-
methylisoquinoline-1(2H)-thione
Unit Weight Unit Price Quantity
100 µmol $918.00
0.25 g $2,225.00
 
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