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BA 0335
Product Information Molecular Structure

Fmoc-amino-modifier III CEP

Notes: For installation of an Fmoc protected amino group internally or at the 5-end of an oligonucleotide.

Description: 

The (fluorenylmethyl)carbamoyl (Fmoc) group has been shown to be useful as such an amine protecting group for amine modification of oligonucleotides.1 It is removed during cleavage/deprotection with ammonium hydroxide. Our new Fmoc-amino Modifier III (BA 0335) contains a 1,3,5-triol framework which serves two functions. First, extended framework disfavors cyclic phosphate formation when the DMT group is removed, thereby minimizing loss of the amine modification. Second, the 1,3,5-triol framework maintains the natural 3-carbon atom internucleotide phosphate distance. 1

We also offer a version of such an Fmoc-protected amino-modifier for installation of an amino group at the 3'-terminus, i.e., 3'-Fmoc-amino-modifier CPG, in both higher- and lower-loaded versions, namely BA 0299 (500 CPG) and BA 0307 (1000 CPG). It features a 7-atom spacer between the amino group and the O-DMT group.

For more information, download a Product Information Sheet for BA 0335 here..

1. Nelson, P. S.; Kent, M.; Muthini, S. Nucl. Acids Res. 1992, 20, 6253-6259.

Fmoc-amino-modifier III CEP
Product Details Product Pricing

MF: C53H64N3O8P

MW: 902.06

CAS NO: 1306615-50-8

Storage Conditions: Dry, -20 C

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Unit Weight Unit Price Quantity
100 µmol $420.00
0.25 g $685.00
 
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