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BA 0324
Product Information Molecular Structure

Cmoc-5'-amino-modifier-C6 CEP

Notes:  Novel acid labile N-protected 5-amino modifier phosphoramidite.

Description: N-protecting groups for 5-amino-modifiers be problematic in automated synthesis. DMT protection is frequently too labile for the amino group. MMT is usually preferred for its greater stability as an N-protecting group, however, it has two practical disadvantages: (1) It requires a custom deprotection protocol since NH-MMT is slightly more robust than O-DMT. (2) Automated synthesizers are designed to quantify DMT cleavage, not MMT cleavage. While the aforementioned Fmoc protected 5-amino-modifiers offer one potential solution to these disadvantages, sometimes it is preferable to have acid-labile N-protection. BA 0324 has a novel N-protecting group that is based upon colorimetric-oxycarbonyl (Cmoc). In essence, the Cmoc group is an O-DMT that is tethered to an N-bis(4-chlorophenyl)-methoxycarbonyl protecting group. Both protecting groups are acid labile, but only the DMT cation generates a colorimetric signal because the tether quenches the bis(4-chlorophenyl)-methyl-carbocation in an intra-molecular fashion, affording a neutral tetrahydrofuran derivative. The acid lability of the Cmoc group allows the choice between on-column deprotection, and off column deprotection. Being more lipophilic than a traditional DMT group, the Cmoc protecting group does a superb job in facilitating SPE purification of full length oligos. If you like the DMT-on purification strategy, you will similarly like the Cmoc-on purification strategy.

For more information, download a Product Information Sheet for BA 0324 here.

Cmoc-5'-amino-modifier-C6 CEP
Product Details Product Pricing

MF: C53H64Cl2N3O7P

MW: 956.97

CAS NO: 1246448-29-2

Storage Conditions: -20 C



Stock maintained. Ships within 1-3 days.

Unit Weight Unit Price Quantity
100 µmol $420.00
0.25 g $685.00
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