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BA 0306
Product Information Molecular Structure

6-Azathymidine CEP

Notes: 6-Azathymidine has a nitrogen atom in place of the methine group at position 6 of the thymine ring. The phosphoramidite 6-Azathymidine CEP (BA 0306) can incorporated into oligonucleotides.

Description: 6-Azathymidine1 has a nitrogen atom in place of the methine group at position 6 of the thymine ring. This results in a significant lowering of the pKa of the N3 hydrogen (7.0)2 vs. that of thymidine (10.0). Hence, 6-azathymidine will be significantly deprotonated at neutral pH.

The phosphoramidite of this nucleoside, 6-Azathymidine CEP (BA 0306) has been incorporated into oligonucleotides,1 where it imparts nuclease resistance when installed at the 5'-position. Duplexes with DNA or RNA are only slightly destabilized, and heteroduplexes with RNA support RNase-H cleavage.

For more information on this product and its use, download a Product Information Sheet here.

ALso available: The phosphoramidite 6-Aza-dU CEP and the nucleosides 6-Azathymidine and 6-Aza-2'-deoxyuridine.

(1) Sanghvi, Y.; Hoke, G. D.; Freier, S. M.; Zounes, M. C.; Gonzalez, C.; Cummins, L.; Sasmor, H.; Cook, P. D. Nucleic Acids Res. 1993, 21, 3197-3203.

(2) Seela, F.; Chittepu, P. J. Org. Chem. 2007, 72, 4358-4366.

6-Azathymidine CEP
Product Details Product Pricing

MF: C39H48N5O8P

MW: 745.80

CAS NO: 142234-18-2

Storage Conditions: -20 oC, dry

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Unit Weight Unit Price Quantity
100 µmol $345.00
0.25 g $895.00
 
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