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BA 0295
Product Information Molecular Structure

Fmoc-pyrrolidine CEP

Notes: Phosphoramidite used to install (2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine (3-hydroxyprolinol) residues into DNA.

Description: Verdine and co-workers1 described the use of Fmoc-pyrrolidine CEP to install (2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine (3-hydroxyprolinol) residues into DNA. Such oligonucleotides were found to be potent and selective inhibitors of E. coli 3-methyladenine DNA glycosylase II (AlkA). The pyrrolidine ring, which should be protonated under experimental conditions, is proposed to mimic the charged intermediate encountered during glycosyl hydrolysis. Related 3-hydroxyprolinol-bearing oligonucleotides have been made and subjected to hybridization studies.2

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(1) Scharer, O. D.; Ortholand, J.-Y.; Ganesan, A.; Ezaz-Nikpay, K.; Verdine, G. L. J. Am. Chem. Soc. 1995, 117, 6623-6624.

(2) Ceulemans, G.; Van Aerschot, A.; Rozenski, J. Herdewijn, P. Tetrahedron 1997, 53, 14957-14974.

Fmoc-pyrrolidine CEP
Product Details Product Pricing

MF: C50H56N3O7P

MW: 841.97

CAS NO: 1221186-22-6

Storage Conditions: -20 oC, dry



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Unit Weight Unit Price Quantity
2 g minimum order, call for pricing $0.00
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