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BA 0269
Product Information Molecular Structure

5-Aminoallyl-U CEP

Notes: Allows the introduction of a 5-aminoallyluridine residue into oligonucleotides for the purpose of post-synthetic labeling by acylation.

Description: To our knowledge, 5-Aminoallyl-U CEP does not appear in the literature. However, the 2'-deoxyribo version (5-Aminoallyl-dU CEP) is known1,2 and is also offered by Berry & Associates (see Product Number BA 0311). It should be noted that the 2'-deoxy version is useful not only in amine modification, but in triplex-forming oligonucleotides (TFOs) that are similar in stability to those bearing unmodified residues.2

For information on the use of this product, download a Product Information Sheet for BA 0269.

1. Early work on the introduction of a 5-aminoallyl-dU amino modifier into oligonucleotides involved the methyl phosphoramidite.1a 5-Aminoallyl-dU CEP (our BA 0311), employing a 2-cyanoethyl phosphoramidite, was reported later.1b See: (a) Cook, A. F.; Vuocolo, E.; Brakel, C. L. Nucleic Acids Res. 1988, 16, 4077-4095. (b) Lermer, L.; Yoann, R.; Ting, R.; Perrin, D. M. J. Am. Chem. Soc. 2002, 124, 9960-9961. See especially the Supporting Information.

2. Brazier, J. A.; Shibata, T.; Townsley, J.; Taylor, B. F.; Frary, E.; Williams, N. H.; Williams, D. M. Nucl. Acids Res. 2005, 33, 1362-1371.

5-Aminoallyl-U CEP
Product Details Product Pricing

MF: C50H65F3N5O10PSi

MW: 1012.133

CAS NO: 1269413-27-5

Storage Conditions: -20 C, dry

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

2'-O-t-Butyldimethylsilyl-3'-O-
[(diisopropylamino)(2-cyanoethoxy)phosphino]-5'-O-
(4,4'-dimethoxytrityl)-5-[E-3-(trifluoroacetamido)-1-
propenyl]uridine
Unit Weight Unit Price Quantity
50 µmol $285.00
0.25 g $995.00
 
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