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BA 0267
Product Information Molecular Structure

8-Aza-7-deaza-A CEP

Notes: 8-Aza-7-deaza-a CEP features a nucleobase that is isosteric with adenine but offers a different pi-electron distribution.

Description: The 2'-deoxyribonucleoside phosphoramidite 8-Aza-7-deaza-dA CEP, also known as PPA CEP, features a nucleobase that is isosteric with adenine but offers a different pi-electron distribution and thus an altered dipole moment, resulting in stronger stacking interactions in oligonucleotides.1 We now offer the ribonucleoside version, 8-Aza-7-deaza-A CEP (PPA Riboside CEP, BA 0267), a new compound, for use in the synthesis of altered RNA oligonucleotides.

Use: 12 min coupling time, standard dilution, standard cleavage/deprotection. Download Product Information.

(1) Seela, F.; Kaiser, K. Helv. Chim. Acta 1988, 71, 1813-1823. Seela describes the N6-benzoyl version of the phosphoramidite of 2'-deoxy-8-aza-7-deaza-A. The N-(dimethylamino)methylidene version of the 2'-deoxy version is available from Berry & Associates (BA 0239) or from Glen Research (#1083).

8-Aza-7-deaza-A CEP
Product Details Product Pricing

MF: C53H66N7O8PSi

MW: 988.19

CAS NO: None Assigned

Storage Conditions: -20 C, dry

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Alternate Name: 

N6-Benzoyl-2'-O-t-butyldimethylsilyl-3'-O-
[(diisopropylamino)(2-cyanoethoxy)phosphino]-5'-O-
(4,4'-dimethoxytrityl)-8-aza-7-deazaadenosine

Alternate Name: 

PPA Riboside CEP
Unit Weight Unit Price Quantity
50 µmol $295.00
100 µmol $475.00
0.25 g $925.00
 
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