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BA 0167
Product Information Molecular Structure

5-Ethynyl-dU CEP

Notes: Replacement of thymidine residues with 5-ethynyl-dU residues results in duplex stabilization. The degree of stabilization is less than that observed with propynyl-dU residues.1

(1) Graham, D.; Parkinson, J. A.; Brown, T. J. Chem. Soc, Perkin Trans. 1 1998, 1131-1138.

Description: Oligonucleotides with 5-ethynyl residues may also be used in transition metal-catalyzed coupling reactions. Two ethynyl-bearing oligonucleotides can be homo-coupled via a diyne linkage using copper catalysis. Further, the ethynyl groups may be used in copper-catalyzed couplings with arylacetylenes bearing anthraquinone, biotin, or fluorescein appendages.2 Palladium catalyzed cross-coupling of ethynyl-dU-bearing oligonucleotidies with 2-iodoanthraquinone provides anthraquinone-bearing nucleic acids useful in electrochemical applications of DNA.3

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(1) Graham, D.; Parkinson, J. A.; Brown, T. J. Chem. Soc, Perkin Trans. 1 1998, 1131-1138.

(2) Minakawa, N.; Ono, Y.; Matsuda, A. J. Am. Chem. Soc. 2003, 125, 11545-11552.

(3) Gorodetsky, A. A.; Green, O.; Yavin, E.; Barton, J. K. Bioconjugate Chem. 2007, 18, 1434-1441.

5-Ethynyl-dU CEP
Product Details Product Pricing

MF: C41H47N4O8P

MW: 754.81

CAS NO: 615288-66-9

Storage Conditions: -20 oC, dry

Purity≥95%

Availability: 

Stock maintained. Ships within 1-3 days.

Unit Weight Unit Price Quantity
100 µmol $200.00
0.25 g $505.00
 
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