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5-Hydroxymethyl-2-deoxycytidine Tools

Click-mates™ Collection

BerrySelect® Reagents for DNA and RNA Synthesis

BlackBerry® Quenchers

Fluorous Affinity Purification of Oligonucleotides

Specialty Chemicals

Special Projects & Collaborations

The Click-mates™ Collection

The Cu(I) catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) also known as the Click reaction (Scheme I), has become an invaluable tool in biochemical research. This cycloaddition reaction is remarkably efficient and reliable even in the presence of the diverse array of functional groups found in DNA and the variety of scientifically intriguing ligation partners. Development of the click methodology has led to the production and study of many modified DNA oligonucleotides (ODNs) for biological as well as nanotechnological and surface oriented applications. The beauty of the click cycloaddition lies in the efficient formation of a non-toxic triazole from biological building blocks that have been modified with non-perturbing azides and unactivated alkynes.

Diagram of the Click reaction

Scheme 1: The CuAAC Reaction

Our Click-mates™ collection includes alkynes for the classic CuAAC, as well as the streamlined copper-free click modifications. The Click-easy™ alkynes can help you to simplify bioconjugation work by employing cyclo-alkynes for efficient uncatalyzed click ligation.

Click-mates™ Alkynes

Click-easy®; Alkynes (For copper-free Click modifications)

Click-mates™ Azides


The purchase of some of these products for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry (“Click Chemistry”) includes a limited, nontransferable license to intellectual property owned by TSRI to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or

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