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Full Catalog (page 22)
Product Number Product Name Molecular Formula Cas. No.

PRA 10035

7-Deazaadenosine (tubercidin)

C11H14N4O4 

69-33-0 

Description

Further discounts available for larger orders. Pricing shown is for tubercidin obtained from fermentation. We also offer synthetic tubercidin, $325.00 (25 mg); $995.00 (100 mg).

PRA 10036

5-Iodo-2'-deoxytubercidin

C11H13IN4O3 

166247-63-8 

PRA 10040

7-Deaza-2'-deoxyguanosine

C11H14N4O4 

86392-75-8 

PRA 10042

7-Methyl-7-deaza-2'deoxyguanosine

C12H16N4O4 

90358-21-7 

PRA 10045

7-Deazaguanosine

C11H14N4O5 

62160-23-0 

Alternate Name(s):

2-Amino-1,7-dihydro-7-β-ribofuranosyl-4-H-pyrrolo[2,3-d]pyrimidin-4-one

PRA 10047

5-Amino-3-β-D-
ribofuranosylthiazolo[4,5-d]
pyrimidin-2,7(3H,6H)-
dione

C10H12N4O6S 

122970-40-5 

Description

Also known as TOG, 7-thia-8-oxoguanosine, Immunosine, Immusine, Isatoribine. An antiviral and immunostimulatory agent that activates, among other things, Toll-like receptor 7 (TLR7). See: Lee, J.; Chuang, T.-H.; Redecke, V.; She, L.; Pitha, P. M.; Carson, D. A.; Raz, E.; Cottam, H. B., Proc. Natl Acad. Sci. USA 2003, 100, 6646-6651 and references therein. Multigram quantities available. Call for pricing.

Notes

An antiviral and immuno-stimulatory agent.

Alternate Name(s):

TOG

7-Thia-8-oxoguanosine

PRA 10050

7-Deaza-2'-deoxyxanthosine

C11H13N3O5 

96022-82-1 

PRA 10055

5'-O-(Dimethoxytrityl)-7-deaza-2'-
deoxyxanthosine

C32H31N3O7 

869355-16-8 

PRA 10060

1-(β-D-2-Deoxyribofuranosyl)-5-
nitroindole

C13H14N2O5 

191421-10-0 

PRA 10070

1-(β-D-2-Deoxyribofuranosyl)-4-
methylindole

C14H17NO3 

180420-84-2 

Notes

This product has been discontinued.

PRA 10080

1-(5-O-(Dimethoxytrityl)-β-D-2-
deoxyribofuranosyl)-4-methylindole

C35H35NO5 

180737-32-0 

Notes

This product has been discontinued.

PRA 10090

1-(5-O-(Dimethoxytrityl)-β-D-2-
deoxyribofuranosyl)-5-nitroindole

C34H32N2O7 

869355-18-0 

PRA 10095

5-Iodotubercidin

C11H13IN4O4 

24386-93-4 

Description

Competitive inhibitor of MAP kinase ERK2. Also inhibits insulin receptor kinase, adenosine kinase, and various serine and threonine kinases. Soluble in DMSO.

Alternate Name(s):

7-Deaza-7-iodoadenosine

ITU

PRA 10100

5'-O-(Dimethoxytrityl)-N2-
(dimethylaminomethylidene)-7-deaza-
2'-deoxyguanosine

C35H37N5O6 

111869-42-2 

PRA 10103

2'-Deoxypseudoguanosine

C10H13N5O4 

912814-74-5 

Description

The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities.  We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.

Pseudo-dG (PRA 10103) is a guanosine isomer that was recently reported by Hosmane and co-workers.1  We also offer Pseudo-dG CEP (BA 0312) , which may be used to incorporate Pseudo-dG nucleotides into DNA.

Pseudo-dG and Pseudo-dG CEP are part of a family that includes Guanosine (PR 3703) , 2'-Deoxyguanosine (PR 3452) , the isomeric nucleosides Isoguanosine (Iso-G, PR 3735) , 2'-Deoxyisoguanosine (Iso-dG, PR 3465) , 2'-Deoxypseudoisoguanosine (Pseudoiso-dG, PRA 10104) , and the phosphoramidite Pseudoiso-dG CEP (BA 0314).

Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers .

1. Ujjinamatada, R. K.; Paulman, R. L.; Ptak, R. G.; Hosmane, R. S. Bioorg. Med. Chem. 2006, 14, 6359-6367.  See also: Ujjinamatada, R. K.; Phatak, P.; Burger, A. M.; Hosmane, R. S. J. Med. Chem. 2008, 51, 694-698.

Notes

2'-Deoxypseudoguanosine (Pseudo-dG) is related to dG by transposition of the nitrogen atom at position 3 and the C-NH2 group at position 2 of the nucleobase, providing a novel hydrogen bond donor/acceptor pattern.

Alternate Name(s):

Pseudo-dG

PRA 10104

2'-Deoxypseudoisoguanosine

C10H13N5O4 

912814-75-6 

Description

The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities.  We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.

Pseudoiso-dG (PRA 10104) is a guanosine isomer that was recently reported by Hosmane and co-workers.1  We also offer Pseudoiso-dG CEP (BA 0314) , which may be used to incorporate Pseudoiso-dG nucleotides into DNA.

Pseudoiso-dG and Pseudoiso-dG CEP are part of a family that includes Guanosine (PR 3703), 2'-Deoxyguanosine (PR 3452), the isomeric nucleosides Isoguanosine (Iso-G, PR 3735), 2'-Deoxyisoguanosine (Iso-dG, PR 3465), 2'-Deoxypseudoguanosine (Pseudo-dG, PRA 10103), and the phosphoramidite Pseudo-dG CEP (BA 0312).

Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers .

1. Ujjinamatada, R. K.; Paulman, R. L.; Ptak, R. G.; Hosmane, R. S. Bioorg. Med. Chem. 2006, 14, 6359-6367.  See also: Ujjinamatada, R. K.; Phatak, P.; Burger, A. M.; Hosmane, R. S. J. Med. Chem. 2008, 51, 694-698 and Berry, D. A.; Wotring, L. L.; Drach, J. C.; Townsend, L. B. Nucleosides Nucleotides 1994, 13, 2001-2011.

Notes

2'-Deoxypseudoisoguanosine (Pseudoiso-dG) is related to Iso-dG by transposition of the nitrogen atom at position 3 and the C-NH2 group at position 2 of the nucleobase, providing a novel hydrogen bond donor/acceptor pattern. It is also related to 2'-Deoxypseudoguanosine (Pseudo-dG) by transposition of the C-NH2 group at position 3 and the carbonyl group at position 6.

Alternate Name(s):

Pseudoiso-dG

PRA 10110

N2-(Dimethylaminomethylidene)-
7-deaza-2'-deoxyguanosine

C14H19N5O4 

111902-68-2 

PRA 10120

9-Deaza-2'-deoxyguanosine

C11H14N4O4 

224946-77-4 

Alternate Name(s):

2-Amino-7-(β-D-2-deoxyribofuranosyl)pyrrolo[3,2-d]pyrimidin-4-one

PRA 10130

9-Deazaguanosine

C11H14N4O5 

102731-45-3 

Alternate Name(s):

2-Amino-7-(β-D-ribofuranosyl)[3,2-d]pyrimidin-4-one

PRA 10140

Sangivamycin

C12H15N5O5 

18417-89-5 

Alternate Name(s):

4-Amino-7-(β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine-5-carboxamide

PRA 10150

Toyocamycin

C12H13N5O4 

606-58-6 

Description

Further discounts available for larger orders. Pricing shown is for toyocamycin obtained from fermentation. We also offer synthetic toyocamycin, $325.00 (25 mg); $995.00 (100 mg). Soluble in acetic acid and acidic solution. Moderately soluble in water, methanol, and ethanol.

Alternate Name(s):

4-Amino-5-cyano-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

Vengicide

PRA 10160

Triciribine

C13H16N6O4 

35943-35-2 

Description

Triciribine (a.k.a. TCN, Tricyclic Nucleoside, NSC-154020) inhibits Akt (protein kinase B) in a very selective fashion, resulting in apoptosis in human cancer cells (Yang L, Dan HC, Sun M Liu Q, Sun X-m, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ, Cancer Research 2004, 64, 4394-4399). It also inhibits DNA synthesis (Wotring LL, Townsend LB, et. al, Cancer Res. 1990, 50, 4891-9), and as its monophosphate, is active against HIV type 1 (Ptak RG, Borysko KZ, Porcari AR, Buthod JL, Holland LE, Shipman C Jr, Townsend LB, Drach JC. AIDS Res. Hum. Retroviruses 1998, 14, 1315-22).

Notes

Triciribine is a tricyclic nucleoside that is cell-permeable and inhibits phosphorylation, activation and signalling of Akt.

Alternate Name(s):

Tricyclic Nucleoside, TCN

(6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine)

PRA 10162

Tricyclic Nucleoside Phosphate

C13H17N6O7P 

61966-08-3 

Description

May be useful in treating cancers with tumors that overexpress Akt, shows antiviral, antineoplastic activity, inhibits enzymes in de novo purine nucleotide synthesis.1,2

(1) Porcari, A. R.; Ptak, R. G.; Borysko, K. Z.; Breitenbach, J. M.; Drach, J. C.; Townsend, L. B. Nucleosides, Nucleotides & Nucl. Acids 2003, 22(12), 2171-2193.
(2) Moore, E. C.; Hurlbert, R. B.; Boss, G. R.; Massia, S. P. Biochem. Pharmcol. 1989, 38(22), 4045-4051.

Notes

Inhibits Akt phosphorylation.

Alternate Name(s):

TCN-P, Triciribine Phosphate

6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine 5'-monophosphate

PRA 10170

8-Aza-7-deaza-2'-deoxyguanosine

C10H13N5O4 

100644-70-0 

Alternate Name(s):

PPG

PRA 10175

6-Amino-2-(2-deoxy-β-D-
ribofuranosyl)-2,5-dihydro-4H-
pyrazolo-[3,4-d]-pyrimidin-4-
one

C10H13N5O4 

109737-94-2 

Alternate Name(s):

iso-PPG

PS 5000

4'-Chloromethyl-4,5',8-
trimethylpsoralen

C15H13ClO3 

62442-57-3 

Description

Nucleophilic displacement of the chloro substituent at the 4' position allows one to attach various linkers to the psoralen ring system.

Notes

Useful building block for incorporation of the psoralen ring system.

Alternate Name(s):

3-Chloromethyl-2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one



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