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Full Catalog (page 20)
Product Number Product Name Molecular Formula Cas. No.

PR 3725

Inosine

C10H12N4O5 

58-63-9 

PR 3727

2',3'-Dideoxyinosine

C10H12N4O3 

69655-05-6 

PR 3730

2',3'-O-Isopropylidene-5'-oxo-
8,5'-cycloadenosine

C13H13N5O4 

33066-26-1 

PR 3732

N6-
Methyladenosine

C11H15N5O4 

1867-73-8 

Alternate Name(s):

N-Methyladenosine

6-Methylaminopurine-D-riboside

PR 3735

Isoguanosine

C10H13N5O5 

1818-71-9 

Description

The transposition of atoms or groups in the purine nucleobase of G/dG provides isomers that have altered base-pairing capabilities. We offer a family of guanosine isomers in nucleoside and phosphoramidite forms.

Isoguanosines are important in the field of non-natural base pairing. In 1989, Benner and co-workers1 reported the enzymatic incorporation of iso-G into RNA and DNA and characterized the distinct non-natural base pairing that resulted, especially pairing involving the similarly transposed isomer of dC known as iso-dC (we offer the closely-related compound 5-Methyliso-dC, PY 7255

Iso-G and Iso-dG are part of a family that includes Guanosine (PR 3703) , 2'-Deoxyguanosine (PR 3452) , the isomeric nucleosides 2'-Deoxypseudoguanosine (Pseudo-dG, PRA 10103) , 2'-Deoxypseudoisoguanosine (Pseudoiso-dG, PRA 10104) and the phosphoramidites Pseudo-dG CEP (BA 0312) and Pseudoiso-dG CEP (BA 0314)

Learn more about these novel compounds and their use by downloading a Product Information sheet for our family of guanosine isomers .

1. Switzer, C. Y.; Moroney, S. E.; Benner, S. A. J. Am. Chem. Soc. 1989, 111, 8322-8323.

Notes

Isoguanosine (Iso-G, PR 3735) and 2'-Deoxyisoguanosine (Iso-dG, PR 3465) are isomeric with G/dG, differing by transposition of the carbonyl group at position 6 of G or dG with the C-NH2 group at position 2, providing a novel hydrogen bond donor/acceptor pattern.

Alternate Name(s):

Iso-G;

2-hydroxy adenosine;

1,2-dihydro-2-oxo adenosine

PR 3740

N6-Methyl-2'-
deoxyadenosine

C11H15N5O3 

2002-35-9 

Description

Methylation of specific adenines in a DNA strand by dam methylase (EC2.1.1.37) is thought to be involved in DNA strand replication during post-replicative mismatch repair and in central gene expression.

PR 3745

N2-Isobutyl-2'-
deoxyguanosine

C14H21N5O4 

142554-22-1 

PR 3748

N1-Methyl-2'-
deoxyguanosine

C11H15N5O4 

5132-79-6 

Description

When incorporated into nucleic acids, may be of use in studies of enzymatic and chemical methylation as well as Tm-leveling studies. Please contact us if you are interested in the cyanoethyl phosphoramidite of this nucleoside for incorporation into oligonucleotides.

Alternate Name(s):

2'-Deoxy-1-methylguanosine

1-Methyl-2'-deoxyguanosine

PR 3750

N2-Methyl-2'-
deoxyguanosine

C11H15N5O4 

19916-77-9 

PR 3755

O6-Methyl-2'-
deoxyguanosine

C11H15N5O4 

964-21-6 

PR 3757

O6-
Methylguanosine

C11 H15 N5O5 

7803-88-5 

PR 3760

2'-O-Methylguanosine

C11H15N5O5 

2140-71-8 

PR 3770

2'-O-Methylinosine

C11H14N4O5 

3881-21-8 

PR 3780

7-Methylinosine

C11H14N4O5 

20245-33-4 

Description

7-Methylinosine is an alternative to MESG for measurement of inorganic phosphate in the presence of purine nucleoside phosphorylase (PNPase).

Rieger, C. E.; Lee, J.; Turnbull, J. L. Anal. Biochem. 1997, 246, 86-95.

PR 3790

7-Methyl-6-thioguanosine

C11H15N5O4S  

55727-10-1 

Description

7-Methyl-6-thioguanosine (MESG, Abs = 330 nm) forms 7-methyl-6-thioguanine (Abs = 355 nm) in the presense of inorganic phosphate and purine nucleoside phosphorylase (PNP) and thus constitutes a rapid and sensitive assay for phosphate. If inorganic pyrophosphatase is present, MESG may also be used to detect inorganic pyrophosphate.

MESG should be used as soon as possible after dissolution.

1. Webb, M. R. PNAS 1992, 89, 4884-4887.

2. Wedler, F. C.; Ley, B. W.; Moyer, M. L. Anal. Biochem. 1994, 218, 449-453.

3. Cheng, J.; Farutin, V.; Wu, Z.; Jacob-Mosier, G.; Riley, B.; Hakimi, B.; Cordes, E. H. Bioorg. Chem. 1999, 27, 307-325.

Alternate Name(s):

MESG

PR 3795

8-Hydroxyguanosine

C10H13N5O6 

3868-31-3 

Alternate Name(s):

8-Oxoguanosine

8-Oxo-G

PR 3796

8-Bromoguanosine

C10H12BrN2O5 

4016-63-1 

Notes

This product has been discontinued.

PR 3797

8-Benzyloxyguanosine

C17H19N5O6 

3868-36-8 

PR 3800

5'-Oxo-8,5'-cycloadenosine

C10H9N5O4 

869355-06-6 

PR 3810

5'-Oxo-2'-deoxy-8,5'-
cycloadenosine

C10H9N5O3 

869355-08-8 

PR 3840

O6-Phenyl-2'-
deoxyinosine

C16H16N4O4 

114485-36-8 

Description

Nucleophilic displacement of the O6-phenyl group offers a convenient route to various 6-substituted purine deoxyribosides.

PR 3842

2-Fluoro-6-O-(2-(4-nitrophenyl)
ethyl)-2'-deoxyinosine

C18H18FN5O6 

132183-39-2 

PR 3843

5'-O-Dimethoxytrityl-2-fluoro-6-
O-(2-(4-nitrophenyl)ethyl)-2'-
deoxyinosine

C39H36FN5O8 

153527-28-7 

PR 3845

6-Thio-2'-deoxyguanosine

C10H13N5O3S 

789-61-7 

PRA 10000

2-Amino-4-chloro-7-(β-D-2-
deoxyribofuranosyl)pyrrolo[2,3-d]
pyrimidine

C11H13ClN4O3 

104291-17-0 

PRA 10005

2-Amino-4-methoxy-7-(β-D-2-
deoxyribofuranosyl)pyrrolo[2,3-d]
pyrimidine

C12H16N4O4 

86392-74-7 



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