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Full Catalog (page 16)
Product Number Product Name Molecular Formula Cas. No.

LK 4260

AmAz Coupler

C25H20NO6P 

532931-48-9 

Description

A modification of the Staudinger azide reduction known as Staudinger ligation provides a way to form an amide bond between an azide containing molecule and an appropriately substituted triaryl phosphine. 1,2 The Staudinger ligation has been used for fluorescent labeling of DNA by site specific ligation of a 5’-azido oligonucleotide with a preformed fluorescein-ligator conjugate.3 The utility of this technology in living systems demonstrates the potential for re-engineering a variety of cell and tissue surfaces.4 Additional applications include site selective post-translational modification of proteins with a biotin-phosphine ligator conjugate,5 ligation of human recombinant thrombomodulin to liver islets through bifunctional poly(ethylene glycol) (PEG) linkers,6 and liposome surface functionalization.7 We now offer LK 4260 as a useful intermediate for the preparation of a variety of ligation conjugates.

LK 4260 and the use thereof in chemoselective ligation, are protected by one or more of the following US Patents, the rights of which are assigned to The Regents of the University of California: US 6,570,040, US 7122703, and US 7,838,665. Additional patents are pending. It may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

1) Saxon, E.; Bertozzi, C.R. Science, 2000, 287, 2007-2010.

2) Saxon, E.; Armstrong, J.I.; Bertozzi, C.R. Org. Lett. 2000, 2, 2141-2143.

3) Wang, C.-Y.; Seo, T.S.; Li, Z.; Ruparel, H.; Ju, J. Bioconjugate Chem. 2003, 14, 697-701.

4) Prescher, J.A.; Dube, D.H.; Bertozzi, C.R. Nature, 2004, 430, 873-877.

5) Ohno, S.; Matsui, M.; Yokogawa, T.; Nakamura, M.; Hosoya, T.; Hiramatsu, T.; Suzuki, M.; Hayashi, N.; Nishikawa, K. J. Biochem. 2007, 141, 335-343.

6) Stabler, C.L.; Sun, X.-L.; Cui, W.; Wilson, J.T.; Haller, C.A.; Chaikof, E.L. Bioconjugate Chem. 2007, 18, 1713-1715.

7) Zhang, H.; Ma, Y.; Sun, X.-L. Chem. Commun. 2009, 3032-3034.

Notes

Our AmAz Coupler allows for the linking of an amine-containing component to an azide-containing component. The amine-containing component is first reacted with the NHS ester and then the azide-containing component is reacted with the phosphine. An intramolecular trapping of the phosphorimidate by the ortho- methyl ester results in a stable aryl-1,4-diamide linkage between the two components.

Alternate Name(s):

4-(2,5-Dioxo-1-pyrrolidinyl)-2-(diphenylphosphino)-1,4-benzenedicarboxylic acid-1-methyl ester

Phosphine ligator N-hydroxysuccinimide ester

LK 4265

AmAz Coupler II

C35H39N2O11P 

None Assigned 

Description

A modification of the Staudinger azide reduction known as Staudinger ligation provides a way to form an amide bond between an azide containing molecule and an appropriately substituted triaryl phosphine. 1,2 The Staudinger ligation has been used for fluorescent labeling of DNA by site specific ligation of a 5’-azido oligonucleotide with a preformed fluorescein-ligator conjugate.3 The utility of this technology in living systems demonstrates the potential for re-engineering a variety of cell and tissue surfaces.4 Additional applications include site selective post-translational modification of proteins with a biotin-phosphine ligator conjugate,5 ligation of human recombinant thrombomodulin to liver islets through bifunctional poly(ethylene glycol) (PEG) linkers,6 and liposome surface functionalization.7 We now offer LK 4265 as a useful intermediate for the preparation of a variety of ligation conjugates.

LK 4265 and the use thereof in chemoselective ligation, are protected by one or more of the following US Patents, the rights of which are assigned to The Regents of the University of California: US 6,570,040, US 7122703, and US 7,838,665. Additional patents are pending. It may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

1) Saxon, E.; Bertozzi, C.R. Science, 2000, 287, 2007-2010.

2) Saxon, E.; Armstrong, J.I.; Bertozzi, C.R. Org. Lett. 2000, 2, 2141-2143.

3) Wang, C.-Y.; Seo, T.S.; Li, Z.; Ruparel, H.; Ju, J. Bioconjugate Chem. 2003, 14, 697-701.

4) Prescher, J.A.; Dube, D.H.; Bertozzi, C.R. Nature, 2004, 430, 873-877.

5) Ohno, S.; Matsui, M.; Yokogawa, T.; Nakamura, M.; Hosoya, T.; Hiramatsu, T.; Suzuki, M.; Hayashi, N.; Nishikawa, K. J. Biochem. 2007, 141, 335-343.

6) Stabler, C.L.; Sun, X.-L.; Cui, W.; Wilson, J.T.; Haller, C.A.; Chaikof, E.L. Bioconjugate Chem. 2007, 18, 1713-1715.

7) Zhang, H.; Ma, Y.; Sun, X.-L. Chem. Commun. 2009, 3032-3034.

Notes

Our AmAz Coupler II allows for the linking of an amine-containing component to an azide-containing component. The amine-containing component is first reacted with the NHS ester and then the azide-containing component is reacted with the phosphine. An intramolecular trapping of the phosphorimidate by the ortho- methyl ester results in a stable aryl-1,4-diamide linkage between the two components.

LK 4270

Aminooxy-TEG-azide

C8H18N4O4 

1306615-51-9 

Description

LK 4270 is a dual purpose linker that has numerous potential applications. Acylation of the oxyamine end affords a hydroxamic acid that bears a TEG-linked azide group. Hydroxamic acids have long been known to be useful as carboxylic acid mimics. Thus, an advantage of LK 4270 is that it allows the introduction of the TEG-azide functionality while retaining comparable acidity to the original carboxylic acid. Alternatively, it is possible for the oxyamine end to condense with an aldehyde, affording an oxime that bears a TEG-linked azide group. Subesquently, the azide group is available for use in a variety of well known ligation paradigms. Click here for examples and additional information.

For a complete listing of our reagents for click chemistry, please see our Click-matesTM Collection page.

The purchase of these products for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry (“Click Chemistry”) includes a limited, nontransferable license to intellectual property owned by TSRI to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.

Notes

A bi-functional linker from our Click-matesTM collection with potential applications in oligonucleotide ligations.

LK 4275

bis-(6-Aminooxyhexyl)
disulfide

C12H28N2O2S2 

None Assigned 

LK 4280

Aminooxy-TEG-propyne

C11H21NO5 

1835759-78-8 

Description

The purchase of these products for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry (“Click Chemistry”) includes a limited, nontransferable license to intellectual property owned by TSRI to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.

LK 4300

Click-easy® MFCO-N-
hydroxysuccinimide ester

C19H25F1N2O5 

1306615-48-4 

Description

Additional examples of bioconjugation with monofluoro substitute cycloalkyne (MFCO) reagents have been reported.1,2

1) Schultz, M.K.; Parameswarappa, S.G.; Pigge, F. C. Organic Lett. 2010, 12, 2398-2401.

2) Martin, M.E.; Parameswarappa, S.M.; O'Dorisio, M.S.; Pigge, F.C.; Schultz, M.K. Bioorg. & Med. Chem. Lett. 2010, 20, 4805-4807.

For a complete listing of our reagents for click chemistry, please see our Click-matesTM Collection page.

LK 4300 is protected by US 7,807,619, the rights of which are assigned to The Regents of the University of California. Additional patents covering methods for their use in the modification of biomolecules are pending. It may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and are not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Notes

Monofluoro-substituted cyclooctyne (MFCO) from our Click-matesTM collection suitable for copper free click reactions.

Alternate Name(s):

2,5-Dioxopyrrolidin-1-yl-6-(1-fluorocycloocty-2-ynecarboxamido)hexanoate

LK 4310

Amino-TEG azide

C8H18N4O3 

134179-38-7 

Description

For a complete listing of our reagents for click chemistry, please see our Click-matesTM Collection page.

The purchase of these products for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry (“Click Chemistry”) includes a limited, nontransferable license to intellectual property owned by TSRI to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.

Notes

A bi-functional linker from our Click-matesTM collection with potential applications in oligonucleotide ligations.

Alternate Name(s):

1-Amino-11-azido-3,6,9-trioxaundecane

Azide-PEG4-amine

LK 4320

Click-easy® BCN N-
hydroxysuccinimide ester I

C15H17NO5 

1426827-79-3 

Description

Please see our Click-matesTM Collection for a selection of click-able azides for use with this remarkable click alkyne.

BCN reagents are sold for research use only under a licensing agreement with Synaffix, B.V.

Notes

A state-of-the-art cyclooctyne for catalyst free strain-promoted, copper-free azide-alkyne cycloadditions.

LK 4330

Click-easy® BCN N-
hydroxysuccinimide ester II

C26H37N3O9 

1314639-16-1 

Description

Please see our Click-matesTM Collection for a selection of click-able azides for use with this remarkable click alkyne.

BCN reagents are sold for research use only under a licensing agreement with Synaffix, B.V.

Notes

A state-of-the-art cyclooctyne for catalyst free strain-promoted, copper-free azide-alkyne cycloadditions.

LK 4340

4-Azidobutyric acid -N-
hydroxysuccinimide ester

C8H10N4O4 

943858-70-6 

Description

For a key reference utilizing this compound, see Grandjean, C.; Boutonnier, A.; Guerreiro, C.; Fournier, J.-M.; Mulard, L. A. J. Org. Chem. 2005, 70, 4407-4410.

The purchase of these products for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry (“Click Chemistry”) includes a limited, nontransferable license to intellectual property owned by TSRI to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or click@scripps.edu.

MN 20001

AICA Riboside (AICAR)

C9H14N4O5 

2627-69-2 

Description

UV abs. Max (water) = 245, 265 nm

Notes

This product has been discontinued.

Alternate Name(s):

5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide

Z-Riboside, Acadesine

PH 1000

TInsP5

C19H64N11O22P5 

None Assigned 

Description

Cleavage of phosphate ester bonds by phytase leads to dephosphorylated T-phosphatidylinositol intermediates that may be quantified using reversed phase chromatography with UV detection.

MF and MW shown are for the decaammonium salt. For the free pentaacid, MF = C19H34NO22P5 and MW = 783.42.

Covered under U.S. Patent NO. 7,741,506

1. Berry, D. F.; Berry, D. A. Tethered phytic acid as a probe for measuring phytase activity. Bioorg. Med. Chem. Lett. 2005, 15(12), 3157-61.

Notes

TInsP5is a novel chromophoric substrate analog of phytic acid that allows the measurement of phytase activity.

Alternate Name(s):

Decaammonium 5-O-[6-(Benzoylamino)hexyl]-myo-inositol-1,2,3,4,6-pentakisphosphate

PH 1200

TET TInsP5

C35H40Cl4NO30P5 (Free Acid) 

None Assigned 

Alternate Name(s):

6-Carboxy TET-TEG-myo-inositol-1,2,3,4,6-pentakisphosphate, Ammonium Salt

PR 3000

5'-O-Acetyl-3'-azido-N2-
palmitoyl-2',3'-dideoxy-guanosine

C28H44N8O5 

144742-33-6 

PR 3005

Adenosine

C10H13N5O4 

58-61-7 

PR 3006

6-N-Acyl-6-N-methyl-2'-
deoxyadenosine

C13H17N5O4 

1377950-60-1 

PR 3007

8-Methyladenosine

C11H15N5O4 

56973-12-7 

PR 3008

Vidarabine

C10H13N5O4 

5536-17-4 

Description

Sold as the hydrate. Sold for research use only - not for use in humans.

Alternate Name(s):

Adenosine arabinoside (Ara-A)

9-β-D-Arabinofuranosyladenine

PR 3010

8-Allyloxy-2'-deoxyguanosine

C13H17N5O5 

869354-71-2 

Description

This product has been discontinued.

PR 3015

8-Allyloxy-N2-
(dimethylaminomethylidene)-2'-
deoxyguanosine

C16H22N6O5 

869354-73-4 

PR 3020

8-Allyloxy-N2-isobutyryl-2'-
deoxyguanosine

C17H23N5O6 

869354-75-6 

PR 3030

2-Aminoadenosine (2,6-
Diaminopurine riboside)

C10H14N6O4 

2096-10-8 

PR 3032

N1-Methyladenosine
hydroiodide

C11H16IO4N5 

208845-22-1 

PR 3040

2-Amino-6-chloro-9-(β-D-2-
deoxyribofuranosyl)purine

C10H12ClN5O3 

120595-72-4 

PR 3045

2-Amino-6-chloro-9-(3,5-di-(p-
toluoyl)-β-D-2-deoxyribofuranosyl)
purine

C26H24ClN5O2 

35095-93-3 

PR 3050

2-Amino-6-chloro-9-(β-D-
ribofuranosyl)purine

C10H12ClN5O4 

2004-07-1 

Alternate Name(s):

6-Chloroguanosine



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