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Full Catalog (page 14)
Product Number Product Name Molecular Formula Cas. No.

FT 6210

6-Carboxytetramethylrhodamine

C25H22N2O5 

91809-67-5 or 150322-06-8 

Alternate Name(s):

6-Carboxy TAMRA

FT 6220

5-Carboxytetramethylrhodamine N-
Hydroxysuccinimide Ester

C29H25N3O7 

150810-68-7 or 321862-17-3 

Alternate Name(s):

5-Carboxy TAMRA N-hydroxysuccinimide ester

FT 6230

6-Carboxytetramethylrhodamine N-
Hydroxysuccinimide Ester

C29H25N3O7 

150810-69-8 

Alternate Name(s):

6-Carboxy TAMRA N-hydroxysuccinimide ester

FT 6240

6-Carboxy-TAMRA TEG azide

C33H38N6O7 

None Assigned 

HC 9000

N2-Acetyl-O6-
(diphenylcarbamoyl)guanine

C20H16N6O3 

112233-74-6 

Description

Vorbruggen glycosylation of this heterocycle with an appropriate carbohydrate yields predominately the N-9 nucleoside. The diphenylcarbamoyl group directs N-9 glycosylation, and is readily removed with ammonia in MeOH.

Notes

This heterocycle can be used for formation of the N-9 nucleoside.

HC 9010

2-Amino-4-chloropyrrolo[2,3-d]
pyrimidine

C6H5ClN4 

84955-31-7 

HC 9012

6-Amino-4-methoxy-1H-
pyrazolo[3,4-d]pyrimidine

C6H7N5O 

100644-67-5 

HC 9015

4-Aminopyrrolo[2,3-d]
pyrimidine

C6H6N4 

1500-85-2 

Alternate Name(s):

7-Deazaadenine

HC 9020

4-Chloropyrrolo[2,3-d]
pyrimidine

C6H4ClN3 

3680-69-1 

Alternate Name(s):

6-Chloro-7-deazapurine

HC 9030

7-Deazaguanine

C6H6N4O 

7355-55-7 

HC 9040

7-Deazahypoxanthine

C6H5N3O 

3680-71-5 

HC 9042

2,6-Dichloropurine

C5H2N4Cl2 

5451-40-1 

HC 9045

7,9-Dimethylguanine

C7H9N5O 

524-35-6 

HC 9050

5-(2-Hydroxyethyl)uracil

C6H8N2O3 

23956-12-9 

HC 9060

6-Methyl-3,7-dihydro-2H-
pyrrolo[2,3-d]pyrimidin-2-
one

C7H7N3O 

663597-69-1 

Description

This heterocycle is a fluorescent analog of cytosine. It is encountered in several of our other products, Pyrrolo-dC (PYA 11090), Pyrrolo-C (PYA 11092), and the phosphoramidites Pyrrolo-dC CEP (BA 0170) and 2'-O-TBS-Pyrrolo-C CEP (BA 0245).

For a leading reference, please see Berry, et. Al, Tetrahedron Lett. 2004, 45 (11), 2457-2461. The phosphoramidites are also available through Glen Research, our development partners in this project. For photophysical studies on these fluorescent pyrrolopyrimidines, see: Thompson, K. C.; Miyake, N., J. Phys. Chem. B, 2005, 109, 6012-6019.


Notes

HC 9060 is a fluorescent analog of cytosine useful in the formation of nucleobases for probing structure and dynamics of nucleic acids.

HC 9070

7-O-Amino-4-
methylumbelliferone

C10H9NO3 

99908-11-9 

Description

Coumarin derivatives such as 7-O-Amino-4-methylumbelliferone have been shown to be useful in a simple spectroscopic assay for aldehydes in biologically relevant media.1 Condensation of this compound with aldehydes (e.g., formaldehyde) forms aldimines that are susceptible to elimination with Lewis bases such as bovine serum albumin (BSA), forming blue-fluorescent 4-methylumbelliferone (4-MU). The excitation and emission maxima for 4-MU are the same at pH 7.0 (water) and pH 10.3 (0.15 M glycine buffer).2 Maximum fluorescence was observed at 445 nm when excited at 365 nm, and the fluorescence intensity is 100 times as intense at pH 10.3 than at pH 7.0.

5 mg = 26.2 micromoles; 25 mg = 131 micromoles.

Download a Product Information Sheet for HC 9070 here.

1. Salahuddin, S.; Renaudet, O.; Reymond, J.-L. Org. Biomol. Chem. 2004, 2, 1471-1475.

2. Strachan, R.; Wood, J.; Hirschmann, R. J. Org. Chem. 1962, 27, 1074-1075.

Notes

Useful in a simple spectroscopic assay for aldehydes in biologically relevant media.

Alternate Name(s):

7-(Aminooxy)-4-methyl-2H-chromen-2-one

HC 9080

MMBC

C20H13NO7 

137350-66-4 

Description

There are several reagents available for the detection and determination of thiols by labeling with a fluorescent reagent.1 MMBC (Methyl maleimidobenzochromenecarboxylate, also known as ThioGlo® 1) was developed by Yang and Langmuir for the detection of thiols.2,3 The maleimide moiety is susceptible to conjugate addition by thiols, converting MMBC, which is essentially nonfluorescent, into highly fluorescent adducts. The advantages of MMBC include: (1) MMBC reacts quickly (ca. 1 min) with thiols under neutral conditions (pH 7.0-7.4). (2) The fluorescent thiol adducts of MMBC have emission maxima at relatively long wavelengths (513 nm), exhibiting high quantum yields. (3) MMBC itself exhibits very little fluorescence at this wavelength (ca. 40-60 times less fluorescent), thus obviating the separation of unreacted starting material from the mixture. (4) MMBC is relatively resistant to hydrolysis at neutral pH. Higher pH's should be avoided (e.g., = 8.0) due to maleimide hydrolysis and nonspecific reactions with amine residues.1

For more information, download a Product Information Sheet for MMBC here.

1. Review: Tyagarajan, K.; Pretzer, E.; Wiktorowicz, J. E. Electrophoresis, 2003, 24, 2348-2358. (Link)

2. Yang, J.-R.; Langmuir, M. E., J. Heterocyclic Chem. 1991, 28, 1177-1180.

3. ThioGlo is a registered trademark of Covalent Associates, Inc.

Notes

Useful in the detection and determination of thiol-containing proteins, enzymes, and peptides. MMBC, which is essentially nonfluorescent, reacts rapidly with thiols at neutral pH to afford highly fluorescent adducts.

Alternate Name(s):

ThioGlo®1; Methyl 10-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-9-methoxy-3-oxo-3H-benzo[f]chromene-2-carboxylate

HC 9090

Pyrroloquinoline quinone (PQQ)

C14H6N2O8 

72909-34-3 

Notes

Coenzyme tailored for efficient oxidation of methanol and formaldehyde in methylotrophic bacteria.

Alternate Name(s):

Methoxatin

4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

HC 9095

Luminol synthon N-
hydroxysuccinimide ester

C18H19N3O6 

1111822-73-1 

Description

Luminol is one of the most widely used chemiluminescent substrates, and luminol based indirect bioassays are linear and efficient. 3-Aminophthalimide derivatives are considered to be “pro-chemiluminescent” substrates since treatment with hydrazine forms a primary amine and free luminol.1 These derivatives are also highly fluorescent and can be used for dual fluorescence and chemiluminescence studies. Our Luminol synthon NHS ester (HC 9095) is designed for post synthetic modification of an oligonucleotide which can then be used as a fluorescent tagged oligo, or treated with hydrazine for chemiluminescence studies.

1. Mavri-Damelin, D.; Wilden, J.; Mani, A.-R.; Selden, C.; Hodgson, H.J.F.; Damelin, L.H. Bioconjugate Chem. 2009, 20, 266-273.

Notes

Luminol precursor

Alternate Name(s):

4-Amino-2-(hexanoic acid-N-hydroxysuccinimide ester)-isoindol-1,3-dione

API-NHS ester

HC 9097

Glutathione reductase probe

C14H11NO6 

1235888-59-1 

Description

Thiols are significant factors in many biological systems, and variations in cellular thiol levels have been associated with a number of disease states including psoriasis, cancer, and AIDS. For this reason, thiol probes that are fast, selective and sensitive are critical in the development of assays that hinge on thiol detection. Xi and co-workers1 have reported on the properties and utility of the coumarin-maleimide as a thiol probe. They have shown that it (HC 9097) is water soluble, has efficient PET quenching, and offers significant turn-on fluorescence in the presence of GSH or cys. They show the Glutathione reductase probe to be highly selective for thiols over competing amino acids, and demonstrated the high sensitivity for low levels of thiols.

References

1. Yi, L.; Li, H.; Sun, L.; Liu, L.; Zhang, C.; Xi, Z.Angew. Chem. Int. Ed. 2009, 48, 4034-4037.

Notes

Fast thiol detection with a probe utilizing coumarin as the fluorophore and maleimide as the thiol acceptor.

Alternate Name(s):

Thiol Fluorescent Probe IV

1173888-41-9

HC 9100

Hydroxy fluorophore I

C21H20N2O3 

1053216-80-0 

Description

Hydroxy fluorophore I is comprable to fluorescein (quantum yield 0.74 and 0.76 respectively.1 Hydroxy fluorophore I has λabs 403 nm and λem 507 nm.

1. Kim, E.; Koh, M.; Ryu, J.; Park, S.B. J. Am. Chem. Soc. 2008, 130 12206-12207.

Notes

A membrane permeable fluorescent probe with pH-independent fluorescence.

Alternate Name(s):

7-Acetyl-1,2-dihydro-2-(2-hydroxy-1-methylethyl)-9-phenyl-3Hpyrrolo[3,4,b]indolizin-3-one

HC 9110

tC Heterocycle

C10H7N3OS 

1207-98-3 

IOPR 3795

8-18O-
Hydroxyguanosine

C10H13N5O518

None Assigned 

Alternate Name(s):

8-Oxoguanosine-18O

LB 7100

Loading Buffer

N/A 

N/A 

Description

Additional information on fluorous affinity purification can be found here. Consists of 5% N,N-dimethylformamide in 100 mg/mL aqueous sodium chloride.

Notes

Used for the fluorous affinity purification of oligonucleotides.

LK 4000

3-(3-Aminopropyl)solketal

C9H19NO3 

131606-42-3 

LK 4005

12-Amino-3,6,9-trioxadodecan-1-ol

C9H21NO4 

49542-66-7 



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